Resident doctors in England will go ahead with a five-day strike this week after rejecting the government’s latest offer aimed at ending a long-running dispute over pay and working conditions.

Formerly known as junior doctors, the physicians, who make up nearly half of England’s medical workforce, will walk out from 07:00 GMT on Wednesday until 07:00 GMT next Monday.

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The action follows an online survey by the British Medical Association (BMA) in which members voted to reject the proposal.

“Tens of thousands of frontline doctors have come together to say ‘no’ to what is clearly too little, too late,” BMA resident doctors committee chairman Jack Fletcher said in a statement, adding that members had rejected the government’s latest offer on working conditions.

Fletcher said the union remained willing to work towards a resolution.

Health Secretary Wes Streeting appealed to doctors to call off the strike.

“There is no need for these strikes to go ahead this week, and it reveals the BMA’s shocking disregard for patient safety,” he said, describing the action as “self-indulgent, irresponsible and dangerous”.

Speaking to Sky News, Streeting said the government was open to the BMA rescheduling the strike to reduce risks to patients during a surge in flu cases.

Flu-related hospitalisations in England rose by more than 50 percent in early December, reaching an average of 2,660 patients a day, the highest level for this time of year. Health leaders have warned there is still no clear peak in sight.

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Across Europe, health authorities are grappling with an unusually early and severe flu season, warning of rising cases across the continent.

The BMA said 83 percent of resident doctors voted to reject the government’s offer with a turnout of 65 percent among its more than 50,000 members.

The offer, made on Wednesday, did not include new pay terms. The BMA has been campaigning for improved pay even before the Labour Party won last year’s general election.

Shortly after taking office, Streeting agreed a deal offering doctors a 22 percent pay rise, short of the 29 percent sought by the union.

The BMA has also called for improvements beyond the 5.4 percent pay increase announced earlier this year, arguing resident doctors continue to suffer from years of pay erosion.

Doctors are seeking “full pay restoration”, meaning a return of salaries to their 2008-2009 levels in real terms before they were eroded by inflation.