Iran’s Supreme Leader Ayatollah Ali Khamenei has warned the United States that joining Israeli strikes on the Islamic Republic will “result in irreparable consequences” for the US, as his and US President Donald Trump’s war of words accelerate and the Israel-Iran hostilities rage for a sixth day.

In his first televised address since Israel began its attacks on Friday, Khamenei said on Wednesday his country “will not surrender to anyone”.

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Iran “will stand firm against an imposed war, just as it will stand firm against an imposed peace”, he said.

Pointedly responding to threatening remarks made a day earlier by Trump, Khamenei said those who know Iran and its history “know that Iranians do not answer well to the language of threat”.

In recent days, Trump has strongly hinted that the US could join in Israel’s military operation against Iran, saying he is seeking something “much bigger” than a ceasefire.

In fresh comments made on Wednesday on the White House lawn at a flag raising ceremony, Trump said “I may do it, I may not do it,” when asked if the US was moving closer to striking Iran.

He claimed, without offering any evidence, that Iran is “totally defenceless, they have no air defence whatsoever”. Iran has said it has had success in bringing down Israeli drones and fighter jets.

“The next week is going to be very big, maybe less than a week,” Trump said, without elaborating.

The US has in recent days sent more warplanes to the region and is also sending the USS Nimitz aircraft carrier.

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The US president claimed Iranian officials reached out to him and suggested visiting the White House, something Iran denies.

“No Iranian official has ever asked to grovel at the gates of the White House. The only thing more despicable than his lies is his cowardly threat to ‘take out’ Iran’s Supreme Leader,” the Iran Mission to the UN said in a post on X.

Trump’s comments came after he demanded on Tuesday Iran’s “unconditional surrender”, saying, “We now have complete and total control of the skies over Iran.” He also boasted that the US could easily assassinate Khamenei.

In an interview with Al Jazeera, Iran’s Ministry of Foreign Affairs spokesman Esmaeil Baghaei echoed Khamenei’s sentiments, warning: “Any American intervention would be a recipe for an all-out war in the region.”

Iran is “under an attack by a genocidal” regime and it will defend itself with “full force” against Israel’s “war of aggression”, Baghaei said.

Significantly, he added he that trusted that Iran’s Arab neighbours will not allow the US to launch attacks from their countries.

Day 6 of Israel Iran hostilities

The warnings were issued as Israel and Iran exchanged fire for a sixth consecutive day. The Israeli military said it struck 40 sites in Iran, including centrifuge production and weapons facilities.

The strikes targeted two centrifuge production facilities – one in Tehran and one in Kahraj – according to the International Atomic Energy Agency (IAEA).

Reporting from Tehran, Al Jazeera’s Tohid Assadi said explosions were heard near the Payam airport in Kahraj, as well as in areas in eastern Tehran. An Iranian government spokesperson also confirmed cyberattacks on at least two of Iran’s banks, he added.

Translation: Another attack near the same previous location in northeast Tehran, Sadr Highway is visible in the footage.

Defence Minister Israel Katz claimed that Israeli jets “destroyed the Iranian regime’s internal security headquarters”, without providing evidence.

Israel’s military confirmed one of its remotely piloted aircraft fell in Iran after being shot at by a surface-to-air missile. “No injuries were reported, and there is no risk of an information breach,” the military said. Iranian state media earlier had said that Iranian forces shot down an Israeli drone and fighter jet.

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‘Crazed’ Israeli attacks

Israeli strikes have continued to target various other areas of Iran, including central Isfahan province. An Israeli strike on a vehicle in Najafabad killed six people, including a pregnant woman and two children, Iran’s Tasnim news agency reported.

According to Iran’s Health Ministry, at least 240 people, including 70 women and children, have been killed since Israel began attacking the country.

In a statement earlier on Wednesday, the Israeli army claimed it is “operating freely” in Iranian skies and said it also shot down 10 Iranian drones, while confirming one of its unmanned aircraft has been downed in Iranian territory.

It also said its forces intercepted an Iranian drone that entered the south of the Israeli-occupied Syrian Golan Heights.

Meanwhile, explosions were heard over Tel Aviv on Wednesday morning as the army said two barrages of Iranian missiles were launched towards the country.

Al Jazeera’s Nour Odeh, reporting from Amman, said Iran’s missile attacks are creating an unprecedented “disruption” of life.

“Over the past six days, the Israeli public has experienced something they haven’t in the past: a formidable army that is firing ballistic missiles at Israeli cities and sensitive Israeli sites,” Odeh said.

They’re seeing “reports in their back yard of dozens of buildings damaged and condemned for demolition,” she said. “There are more than 1,300 Israelis who now have to live in hotels because their homes are unliveable, damaged beyond repair.”

The attacks have continued to cause global concern, with many countries expressing the need for de-escalation.

Russian President Vladimir Putin reiterated his country’s willingness to help mediate the crisis.

Speaking to members of his ruling Justice and Development Party in parliament, Turkish President Recep Tayyip Erdogan said his country wants to see the crisis resolved diplomatically and Ankara could play a constructive role.

Erdogan accused Israel of waging “crazed” attacks against Iran that amount to “state terrorism”.

Iran’s response, he said, is natural, legal and legitimate.

Hassan Ahmadian, an associate professor at the University of Tehran, says he doubts the prospects for any diplomatic solution between Iran and the US.

“The minimal trust that led to the negotiations with the US is currently nonexistent,” Ahmadian said, adding that many Iranians now view the previous round of nuclear talks as little more than a distraction before the surprise Israeli attack.

“I don’t see much of a chance for diplomacy at this point – not until this confrontation ends and we see what comes next,” he told Al Jazeera.