President Donald Trump has urged Iran to agree to US demands to restrict its nuclear programme as Tehran promised a strong response to Israeli air strikes targeting its nuclear sites and military facilities, killing at least two senior military commanders and several nuclear scientists.

Writing on his Truth Social platform on Friday, Trump warned that the “next already planned attacks” on Iran would be “even more brutal” and urged Iranian officials to “make a deal before there is nothing left”.

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“Iran must make a deal, before there is nothing left… JUST DO IT, BEFORE IT IS TOO LATE,” he said.

In another post on his social media platform, the US president later said that Iran may have a second chance after claiming he gave Tehran 60 days to make a deal two months ago.

“I told them what to do, but they just couldn’t get there. Now they have, perhaps, a second chance!”

Secretary of State Marco Rubio earlier said that the United States had no part in the Israeli attacks and urged Iran not to target American interests or personnel in the region in retaliation, but Tehran said Washington would be “responsible for consequences”.

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Iran promised a harsh response against Israel, and the Israeli military said early on Friday that it was trying to intercept about 100 drones launched towards Israeli territory in retaliation.

Iranian state media has reported that Hossein Salami, commander-in-chief of the Islamic Revolutionary Guard Corps, and Mohammad Bagheri, the chief of staff of Iran’s Armed Forces, were both killed in the attacks. Nuclear scientists Mohammad Mehdi Tehranchi and Fereydoun Abbasi were also killed.

Some 200 Israeli warplanes took part in overnight air strikes on Iran, hitting more than 100 targets in the country, according to Israeli army spokesman, Brigadier General Effie Defrin.

Prime Minister Benjamin Netanyahu said Israel struck at the “heart of Iran’s nuclear enrichment programme”, taking aim at the main uranium enrichment facility in Natanz.

The attacks would “continue as many days as it takes”, he said.

Iranian media reported explosions, including some at the main uranium enrichment facility at Natanz. Iran’s Atomic Energy Organisation said Natanz had sustained damage but no casualties had been reported.

On Friday afternoon, Iran’s Tasnim news agency reported a new Israeli attack in the city of Tabriz, northwest of Iran.

Iran’s Fars news agency reported that at least 78 people were killed and more than 320 others were injured in the attacks, citing “unofficial statistics”.

‘Severe punishment for Israel’

Iran’s Supreme Leader Ayatollah Ali Khamenei warned Israel that it “must expect severe punishment” after the assault. The country’s Ministry of Foreign Affairs added that Tehran has a “legal and legitimate” right to respond.

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Iranian President Masoud Pezeshkian said Israel would “regret” its attacks.

“The Iranian nation and the country’s officials will not remain silent in the face of this crime, and the legitimate and powerful response of the Islamic Republic of Iran will make the enemy regret its foolish act,” Pezeshkian said in a video statement broadcast on state television.

Israel’s military said on Friday it was intercepting Iranian drones. The country’s public broadcaster and Channel 12 reported that Israel also intercepted drones over Saudi Arabia.

At about 08:00 GMT, Israeli media reported that an earlier order requiring citizens to remain near protected areas had been lifted.

In the Iranian city of Qom, hundreds of protesters gathered at the Jamkaran Mosque to demand a “severe punishment” for Israel in response to the strikes.

Mohammad Eslami, a research fellow at Tehran University, said Iranian leaders are preparing an imminent strike on Israel targeting military and nuclear facilities.

“The Iranian military were thinking about this scenario for many years and also in recent days, we have heard lots of statements by the Defence Ministry of Iran that they are ready for any strike by the Israelis,” he told Al Jazeera from Tehran.

“Most Iranian political parties support defending the country because all Iranians [know] the history of Iraq attacking Iran. This is not about political points of view,” he added.

Nuclear talks

US and Iranian officials are due to attend a sixth round of talks over Iran’s nuclear programme in Oman on Sunday.

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The two sides have been negotiating over Iran’s enrichment of uranium, with Trump stating recently that “zero” enrichment should be allowed in Iran. He has also said repeatedly that Iran will not be allowed to obtain nuclear weapons.

Tehran has consistently said that its nuclear programme is only for civilian purposes.

Iran said in a statement that Israel’s “cowardly” attack showed why Iran had to insist on enrichment, nuclear technology and missile power.

The International Atomic Energy Agency’s Board of Governors on Thursday declared Iran in breach of its non-proliferation obligations for the first time in almost 20 years.