International nonprofit organisation Freedom Flotilla Coalition (FFC) says one of its vessels has left Sicily to deliver humanitarian aid to Gaza, after a previous attempt failed due to a drone attack on a different ship in the Mediterranean.

The 12-person crew, which includes Swedish climate activist Greta Thunberg, Irish actor Liam Cunningham and Franco-Palestinian MEP Rima Hassan, set sail on the Madleen from the port of Catania on Sunday, carrying barrels of relief supplies that the group called “limited amounts, though symbolic”.

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The voyage comes after another vessel operated by the group, the Conscience, was hit by two drones just outside Maltese territorial waters in early May. While FFC said Israel was to blame for the incident, it has not responded to requests for comment.

“We are doing this because no matter what odds we are against, we have to keep trying, because the moment we stop trying is when we lose our humanity,” Thunberg told reporters at a news conference before the departure. The Swedish climate activist had been due to board the Conscience.

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She added that “no matter how dangerous this mission is, it is nowhere near as dangerous as the silence of the entire world in the face of the lives being genocised”.

The activists expect to take seven days to reach their destination, if they are not stopped.

The FCC, launched in 2010, is a non-violent international movement supporting Palestinians, combining humanitarian aid with political protest against the blockade on Gaza.

It said the trip “is not charity. This is a non-violent, direct action to challenge Israel’s illegal siege and escalating war crimes”.

United Nations agencies and major aid groups say Israeli restrictions, the breakdown of law and order, and widespread looting make it extremely difficult to deliver aid to Gaza’s roughly two million inhabitants.

The situation in Gaza is at its worst since the war between Israel and Hamas began 19 months ago, the UN said on Friday, despite a resumption of limited aid deliveries in the Palestinian enclave.

Under growing global pressure, Israel ended an 11-week blockade on Gaza on May 19, allowing extremely limited UN-led operations to resume.

On Monday, a new avenue for aid distribution was also launched: the Gaza Humanitarian Foundation, backed by the United States and Israel, but with the UN and international aid groups refusing to work with it, saying it is not neutral and has a distribution model that forces the displacement of Palestinians.

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The FCC is the latest among a growing number of critics to accuse Israel of genocidal acts in its war in Gaza, allegations Israel vehemently denies.

“We are breaking the siege of Gaza by sea, but that’s part of a broader strategy of mobilisations that will also attempt to break the siege by land,” said activist Thiago Avila.

Avila also mentioned the upcoming Global March to Gaza – an international initiative also open to doctors, lawyers and members of the media – which is set to leave Egypt and reach the Rafah crossing in mid-June to stage a protest there, calling on Israel to stop the Gaza offensive and reopen the border.